Hermen Overkleeft

Titels Prof. dr.
Initials H.S.
Main position Hoogleraar UL, Wetenschappelijk Directeur Leiden Institute of Chemistry (LIC)
Disciplines Organic chemistry
Chair Bio-organische chemie
Domain Natural Sciences and Engineering
Membership Member
Since 2018
Member of Council for Natural Sciences and Engineering
Member of Natural Sciences and Engineering
Employed by Universiteit Leiden
Gorlaeus Laboratories
Einsteinweg 55
2333 CC Leiden
tel.  071 527 4342
Personal website

Hermen Overkleeft wants to understand biological processes at the molecular level. He combines organic chemistry with glycobiology and immunology. For example, he designs reactive molecules that react with different classes of enzymes – both proteases and glycosidases – and subsequently remain irreversibly bonded. Using this toolkit, he has developed diagnostic agents that can be used in a variety of disorders, from haematological cancers to lysosomal storage diseases. These reagents can also be used in the search for compounds that could influence these diseases.