| Titels | Prof. dr. |
| Initials | H.S. |
| Main position | Hoogleraar UL, Wetenschappelijk Directeur Leiden Institute of Chemistry (LIC) |
| Disciplines | Biochemistry |
| Organic chemistry | |
| Chair | Bio-organische chemie |
| Domain | Natural Sciences and Engineering |
| Membership | Member |
| Since | 2018 |
| Member of Natural Sciences and Engineering | |
| Employed by |
Universiteit Leiden
Gorlaeus Laboratories Einsteinweg 55 2333 CC Leiden tel. 071 527 4342 h.s.overkleeft@chem.leidenuniv.nl |
| Personal website | |
| Research/publications |
Hermen Overkleeft wants to understand biological processes at the molecular level. He combines organic chemistry with glycobiology and immunology. For example, he designs reactive molecules that react with different classes of enzymes – both proteases and glycosidases – and subsequently remain irreversibly bonded. Using this toolkit, he has developed diagnostic agents that can be used in a variety of disorders, from haematological cancers to lysosomal storage diseases. These reagents can also be used in the search for compounds that could influence these diseases.