|Histology, cell biology|
|Domain||Medical, Biomedical and Health Sciences|
Erasmus MC, University Medical Center Rotterdam
Dept. of Genetics, Dept. of Radiation Oncology
3000 CA Rotterdam
tel. 010 704 3168
Roland Kanaar has made an important contribution to our understanding of genetic stability in relation to cancer and congenital disorders. In his research, he investigates the process of DNA damage and recovery at all levels. Cells can repair quite a lot of damage; unfortunately, they also repair damage to tumours induced by radiation therapy. Kanaar recently demonstrated that one of the DNA repair systems is deactivated when a tumour is heated to 42 degrees Celsius. Combined with medication, this may offer certain cancer sufferers an effective new treatment.