Academy Colloquium

Stochastic Single-Cell Dynamics in Immunology: Experimental and Theoretical Approaches

17 June 2015  -  19 June 2015
KNAW, Trippenhuis, Kloveniersburgwal 29, 1011 JV Amsterdam
020 551 0747
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The colloquium consists of a two-day main event in which internationally renowned experts will discuss both experimental and modelling work, followed by a one-day workshop with tutorials on advanced methodology suitable for analysing and modelling stochastic single-cell data. In addition to scientific presentation, ample time will be dedicated for informal discussion and poster viewing.

Cells of the immune system are exceptionally diverse. As a consequence, immunological processes such as the formation of an immune response may depend on the fates of individual cells. Experimental and theoretical studies have traditionally been restricted to study events at the population level. The advent of novel experimental techniques like single cell imaging, cellular barcoding, microfluidics, and deep sequencing now allows immunologists to directly investigate single-cell events. Results obtained in these studies suggest that migration, activation, differentiation, and proliferation of immune cells are highly stochastic.

In large high-dimensional datasets, it is notoriously challenging to distinguish stochastic fluctuations from biological meaningful features. Advanced data analysis techniques and mathematical modelling are thus emerging as key tools for this field.

T cells (green) attacking herpes-infected skin cells (red)

Heatmap vizualization of cellular barcoding data

To advance basic research in this area of immunology, and to leverage these advances towards practical applications in disease treatment and prevention, it is essential for experimental immunologists, theoretical immunologists, and statisticians to engage in an interdisciplinary dialogue.  This colloquium will develop closer ties between researchers in these different communities, and help bridge the “culture gap” between theoretical and experimental approaches.

Confirmed Speakers

  • Dirk Busch (Technische Universität München, DE)
  • Ido Amit (Weizmann Institute, IL)
  • Gregoire Altan-Bonnet (Memorial Sloan-Kettering Cancer Center, USA)
  • Philippe Bousso (Institut Pasteur, F)
  • Joost Beltman (Universiteit Leiden, NL)
  • Nienke Vrisekoop (Universiteit Utrecht, NL)
  • Ehud Shapiro (Weizmann Institute, IL)
  • Phil Hodgkin (Walter & Eliza Hall Institute for Medical Research, AUS)
  • Timm Schroeder (Helmholtz Center München, DE)
  • Ken Duffy (National University of Ireland, IE)
  • Victoria Sanz Moreno (King’s College London, UK)
  • Grant Lythe (University of Leeds, UK)
  • Joris Mooij (University of Amsterdam, NL)
  • Susan Stepney  (University of York, UK)
  • Thomas Jansen (Aberystwyth University, UK)

Participation and abstract submission

Participants to the colloquium will be selected on the basis of their submitted abstract (200 words). All participants will be invited to present a poster. Please submit a brief description (300 words max) of your relevant research and your motivation for participating in the colloquium.

Registration fee: EUR 100 include lunches and welcome reception

Capacity: 30 participants

Organising and scientific committee

  • Dr. Leïla Perié (Universiteit Utrecht & NKI Amsterdam)
  • Dr. Johannes Textor (Universiteit Utrecht)
  • Prof. Rob de Boer (Universiteit Utrecht)
  • Prof. Ton Schumacher (NKI Amsterdam)