First patient-derived organoid model for cervical cancer

13 April 2021

Researchers from the group of Hans Clevers (Hubrecht Institute) developed the first patient-derived organoid model for cervical cancer. They also modelled the healthy human cervix using organoids. In close collaboration with the UMC Utrecht, Princess Máxima Center for pediatric oncology and the Netherlands Cancer Institute, the researchers used the organoid-based platform to study sexually transmitted infections for a herpes virus. 

The model can potentially also be used to study the human papillomavirus (HPV), which is one of the main causes of cervical cancer. The results were published in Cell Stem Cell on the 13th of April.

Cervical cancer is a common gynecological malignancy, often caused by the human papillomavirus (HPV). However, good models to study human cervical tissues were lacking. Reason enough for the group of Hans Clevers to develop an organoid-based model for the healthy cervix and associated malignancies including cervical cancer. The project was conducted in close collaboration with researchers from the UMC Utrecht, the Princess Máxima Center for pediatric oncology and the Netherlands Cancer Institute.  

Read the full article on the Hubrecht Institute website.

Hubrecht Institute

The Hubrecht Institute is a research institute focusing on developmental and stem cell biology. It encompasses 24 research groups that perform fundamental and multidisciplinary research, both in healthy systems and disease models. The Hubrecht Institute is a research institute of the Royal Netherlands Academy of Arts and Sciences (KNAW)., located on the Utrecht Science Park ‘De Uithof’. Since 2008, the institute has been affiliated with the University Medical Center Utrecht, advancing the translation of research into clinical practice. The Hubrecht Institute has a partnership with the European Molecular Biology Laboratory (EMBL). 

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