Press release Hubrecht Institute

15 September 2017

Researchers at Hubrecht Institute, UMC Utrecht and Princess Máxima Center have developed a method, based on CRISPR-Cas9 technology in organoids, to study the genetic cause of hereditary forms of cancer. This method can be of great significance for the diagnosis and treatment of multiple forms of cancer.

Their study shows that by examining a tumour’s DNA, a familial cause of colon and breast cancer can be identified, for example, through a germline mutation in the NTHL1 gene. The publication was published in Science on 14 September 2017.

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About the Hubrecht Institute

The Hubrecht Institute is a research institute of the Royal Netherlands Academy of Arts and Sciences. Presently there are 20 research groups with a total of about 200 employees. In addition to a highly interactive and international scientific environment, excellent research facilities are available for imaging and functional genomics. Moreover, several model organisms are present, including C. elegans, zebrafish and mice. The institute is situated in Utrecht at the university centre De Uithof. The Hubrecht Institute is affiliated with the University Medical Center Utrecht and has close connections with Utrecht University, e.g. in the Graduate School Cancer Genomics and Development Biology.

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