Scientists at the University Medical Center (UMC) Utrecht and the Hubrecht Institute have managed to detect errors in the DNA code of healthy human stem cells for the first time. They found that stem cells in organs with a high cancer risk collect the same amount of DNA–errors as organs with a low cancer risk.
This surprising finding shows that the probability of cancer cannot be explained by the number of DNA–errors. The study is published in Nature, 3 October 2016.
About the Hubrecht Instituut
The Hubrecht Institute is a research institute of the Royal Netherlands Academy of Arts and Sciences. Presently there are 20 research groups with a total of about 200 employees. In addition to a highly interactive and international scientific environment, excellent research facilities are available for imaging and functional genomics. Moreover, several model organisms are present, including C. elegans, zebrafish and mice. The institute is situated in Utrecht at the university centre De Uithof. The Hubrecht Institute is affiliated with the University Medical Center Utrecht and has close connections with Utrecht University, e.g. in the Graduate School Cancer Genomics and Development Biology.